CAS 25655-41-8 Povidone-Iodine: Specifications, Uses, and Sourcing Guide

CAS 25655-41-8 identifies povidone-iodine, a complex of iodine and the polymer povidone (PVP) used as an antiseptic ingredient in pharmaceutical and healthcare products. For B2B buyers, the central specification to verify is available iodine: many pharmaceutical-grade materials are specified within a range such as 9.0–12.0%, but the applicable limit depends on the agreed grade and current specification. Before purchasing, match the material to the intended formulation, confirm its documentation and test requirements, and request a current quotation from the supplier.

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Key Takeaways

• CAS 25655-41-8 refers to povidone-iodine, also called PVP-I, an iodine–povidone complex.
• Available iodine content is a key measure of strength; confirm the exact assay range and method for the offered grade.
• Applications commonly include topical antiseptic formulations and other products where an iodine-releasing ingredient is appropriate.
• Evaluate the specification, regulatory documentation, packaging, minimum order quantity, and lead time together—not as separate purchasing decisions.
• NKY Group can discuss B2B requirements for CAS 25655-41-8 and confirm supply details against the buyer’s destination and project needs.

Who This Guide Is For

This guide is intended for pharmaceutical manufacturers, formulation teams, distributors, procurement professionals, and importers evaluating povidone-iodine as a raw material. It is also useful for buyers comparing supplier offers that use similar product names but may differ in grade, assay range, or documentation. The information is a sourcing overview, not a substitute for a current pharmacopeial monograph, product specification, or local regulatory review.

What Is Povidone-Iodine?

Identity and basic function

Povidone-iodine is a complex formed from iodine and povidone, a water-soluble polymer. The polymer acts as a carrier for iodine, from which iodine can be released in solution. This chemistry underlies its use as an antiseptic ingredient in appropriate topical products.

Because povidone-iodine is a complex rather than a simple small molecule with one fixed molecular formula, buyers should not rely on a molecular-weight value as the principal identity check. Confirm the product name, CAS number, grade, assay basis, and applicable test methods on the supplier’s documentation. For a pharmaceutical application, the buyer’s quality team should also verify that the offered material meets the requirements of the intended market and formulation.

Specifications and Material Options

Key specification to review

Available iodine is a defining quality attribute for many povidone-iodine grades. A commonly encountered pharmaceutical specification range is 9.0–12.0% available iodine, but buyers should treat this as a general reference, not as a guaranteed NKY Group product result or a universal limit. The controlling value must come from the current grade-specific specification and the agreed purchasing documents.

Other items that may appear in a product specification include appearance, identification, loss on drying or moisture-related limits, pH, residue, and impurity tests. Which tests apply, their acceptance criteria, and their methods can vary by grade, pharmacopoeial standard, and intended use. Ask for the actual specification and a representative certificate of analysis (COA) for the offered product rather than assuming that a generic list describes every lot.

Raw material versus formulated product

Buyers should distinguish the bulk ingredient from a finished solution or other ready-to-use product. For example, a commonly labeled 10% povidone-iodine solution may represent approximately 1% available iodine when formulated on that basis; this is a formulation concentration, not the same thing as the available-iodine assay of the raw material. Confirm whether a quotation is for bulk PVP-I or a finished preparation, and define concentration units clearly.

Uses and Application Matching

Povidone-iodine is used in topical antiseptic products, including products intended for skin preparation or wound-related applications, subject to formulation design and local rules. Its suitability depends on the product’s intended use, route of application, target market, and applicable labeling or regulatory requirements. A raw material supplier can provide product information, but the finished-product manufacturer remains responsible for formulation safety, efficacy, and compliance.

For formulation development, assess compatibility with the full ingredient system, product stability, packaging, and the desired iodine concentration. Do not select a grade solely because its name matches the target ingredient: assay, quality limits, and documentation must also align with the product’s requirements. Where a product is intended for a regulated market, involve regulatory and quality teams before finalizing the purchase specification.

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How to Select a Grade and Supplier

A practical selection framework

1. Define the application. State whether the material is for pharmaceutical formulation, distribution, development, or another use, and identify the destination market.
2. Set the specification. Agree on available iodine limits, required tests, acceptance criteria, and test methods before requesting a final offer.
3. Review documentation. Check that the product specification and lot COA identify the material and report the agreed quality attributes. Request additional documents only where they are needed for your quality system or market.
4. Confirm supply terms. Clarify pack size, order quantity, shipping terms, destination, lead time, and any sampling or pre-shipment review requirements.
5. Approve the supplier. Assess communication, traceability, document consistency, and the supplier’s ability to address your technical and logistical requirements.

A useful supplier comparison separates mandatory requirements from preferences. For example, the assay limit and traceability documents may be pass-or-fail criteria, while packaging format or shipment timing may be negotiable. Recording these priorities in one request for quotation helps suppliers respond on a comparable basis and reduces the risk of comparing offers for different grades.

Pricing, MOQ, and Lead Time

Pricing for CAS 25655-41-8 is quote-dependent rather than a fixed figure that can be inferred from the CAS number. The offer may vary with grade, order quantity, packaging, documentation needs, destination, and current availability. Buyers should request a quotation that states the quoted product specification, quantity, currency, delivery basis, and offer validity.

Minimum order quantity and lead time should also be confirmed directly for the requested grade and shipment. These terms can change with order size, packaging, production or inventory status, and export arrangements, so a general estimate should not be treated as a commitment. For project planning, request both the expected dispatch schedule and any conditions that could affect it.

Supplier Evaluation Checklist

Before placing an order, check that the supplier can identify the offered material clearly and provide the agreed quality documents. Confirm that the lot COA corresponds to the shipment and that the specification uses the same assay basis and test methods as your purchase requirement. If your organization needs additional documentation, agree on its availability and timing before the order is finalized.

Also review packaging suitability, transport arrangements, labeling, and communication during order processing. Avoid treating a low price as evidence of equivalent quality when the grade or documentation has not been compared. If a requirement is unclear, resolve it in writing before approving the purchase order.

How NKY Group Supports B2B Sourcing

NKY Group works with B2B buyers seeking CAS 25655-41-8 povidone-iodine as a manufacturer, supplier, and exporter. We can review your target grade, intended application, assay requirement, quantity, destination, and documentation needs to help define a suitable inquiry. Specific product specifications, available packaging, MOQ, lead time, and shipping arrangements should be confirmed for each request.

To support an efficient quotation, include your required available-iodine range, applicable quality standard, target order quantity, destination country, and any required documents. If you are comparing suppliers, share the points that are mandatory for qualification so the offer can address them directly. We recommend approving the current specification and commercial terms before confirming an order.

Conclusion: Next Steps for Buyers

CAS 25655-41-8 is the identifier for povidone-iodine, an iodine–povidone complex used as an antiseptic ingredient in appropriate formulations. The most important starting point is to verify the available-iodine assay and then match the offered grade, test methods, and documentation to the product and market requirements. A general reference range such as 9.0–12.0% is not a substitute for the supplier’s current, grade-specific specification.

Before sourcing, define your application, prepare a written specification, and compare supplier documentation and delivery terms alongside price. Contact NKY Group with your grade, quantity, destination, and document requirements to discuss availability and request a B2B quotation. Finalize the purchase only after your technical, quality, and regulatory teams approve the material for its intended use.