Sep. 22, 2026
Chemicals
3-Fluoro-2-methylbenzeneboronic acid is an aromatic boronic acid used primarily as a synthetic building block in medicinal chemistry, pharmaceutical research, and advanced organic synthesis. Its CAS number is 163517-61-1, and its molecular formula is generally represented as C7H8BFO2, with a calculated molecular weight of approximately 153.95 g/mol. At Maison Chemical, I position this compound as a research and manufacturing intermediate that buyers should evaluate by identity, purity, documentation, packaging, and suitability for their specific reaction route.
The molecule combines three useful structural features: an aryl boronic acid group, a fluoro substituent, and a methyl substituent. The boronic acid group supports carbon–carbon bond-forming chemistry, while fluorine and methyl substitution can influence the electronic and steric behavior of the aromatic ring. Because commercial specifications and physical appearance may vary by supplier and production batch, I recommend confirming the current specification sheet and certificate of analysis before purchase.
3-Fluoro-2-methylbenzeneboronic acid belongs to the family of substituted arylboronic acids. Its boronic acid functionality contains boron bonded to two hydroxyl groups, while the aromatic ring carries fluorine and methyl substituents. This combination gives chemists a defined starting point for introducing a substituted aryl fragment into more complex molecules.
The reported formula, C7H8BFO2, corresponds to an approximate molecular weight of 153.95 g/mol. The compound is normally handled as a solid chemical intermediate, although the precise color, particle form, assay, water content, and storage conditions should be verified from the supplier’s current technical documents. I do not recommend relying on a generic catalog description when the material is intended for a regulated or scale-sensitive process.
Like other boronic acids, this compound may participate in reactions that are affected by moisture, pH, solvent choice, base selection, catalyst system, and reaction temperature. Its exact behavior depends on the reaction design rather than on the boronic acid alone. For this reason, I treat published reaction examples as starting points for development, not as guaranteed process conditions.
The most important use of 3-fluoro-2-methylbenzeneboronic acid is as an aryl donor in Suzuki–Miyaura cross-coupling. In a typical coupling, the arylboronic acid reacts with an aryl or vinyl halide in the presence of a suitable palladium catalyst, base, solvent, and controlled reaction conditions. The result can be a biaryl or related carbon–carbon bonded product containing the fluoro-methyl-substituted aromatic unit.
This transformation is valuable because it allows chemists to assemble complex aromatic structures from comparatively modular fragments. The actual yield and selectivity depend on the electrophile, catalyst, ligand, base, solvent, concentration, and purification strategy. I therefore recommend small-scale compatibility screening before committing to larger material volumes.
In medicinal chemistry, fluorinated and methyl-substituted aromatic groups are frequently explored when researchers are adjusting molecular size, lipophilicity, conformation, or electronic properties. This does not mean that every product containing this fragment will show a particular biological effect. Instead, 3-fluoro-2-methylbenzeneboronic acid provides a practical route for preparing structural analogues during a discovery program.
The compound may also be relevant to the preparation of advanced intermediates for pharmaceutical, agrochemical, and specialty-material research. Its value is highest when the target route specifically benefits from the substitution pattern and the coupling handle. A buyer should compare it with alternative substituted boronic acids based on route efficiency, downstream purification, and final product requirements.
The most suitable application is determined by the customer’s target structure and reaction sequence. I advise buyers to share the intended reaction type, approximate batch size, and required purity range when requesting a quotation. That information helps avoid supplying a material format that is technically correct but unsuitable for the planned process.
For procurement purposes, buyers may compare neat solid material, different pack sizes, and different purity or documentation packages. Not every supplier offers every option, so availability should be confirmed before an order is placed. If a solution format, special packaging, or custom quantity is required, the supplier should confirm whether that format is technically and commercially feasible.
With competitive price and timely delivery, Maison Chemical sincerely hope to be your supplier and partner.
| Specification Area | What the Buyer Should Confirm |
|---|---|
| Identity | Compound name, CAS 163517-61-1, formula, and analytical identification |
| Purity | Assay method, stated purity target, and applicable impurity limits |
| Physical form | Solid appearance, particle characteristics, and net weight |
| Documentation | Certificate of analysis, safety data sheet, and batch information where available |
| Packaging | Container type, labeling, tamper protection, and shipment requirements |
I recommend treating the certificate of analysis as batch-specific evidence rather than assuming that a website specification applies identically to every shipment. Relevant tests may include chromatographic purity, identity confirmation, water content, residual solvents, and other customer-defined parameters. The appropriate test panel depends on the intended use and the customer’s quality system.
3-Fluoro-2-methylbenzeneboronic acid should be handled by trained personnel using the applicable safety data sheet, laboratory procedures, and local chemical regulations. I recommend using appropriate gloves, eye protection, laboratory clothing, and engineering controls suitable for the operation. The SDS should be reviewed before opening the container because hazard classification, transport status, and recommended controls must be confirmed for the actual supplied material.
Storage should follow the supplier’s label and SDS instructions. In practice, buyers should keep the container properly closed, protect the material from contamination, and avoid unnecessary exposure to heat, humidity, or incompatible substances. If moisture sensitivity is identified in the product documentation, moisture-controlled handling and resealing after use become especially important.
For production or scale-up work, the buyer should also assess charging procedures, dust control, waste disposal, and compatibility with the selected solvent and base system. I do not recommend transferring a laboratory handling assumption directly into plant operations without a documented process-safety review. The final control measures should be determined by the customer’s qualified safety and technical teams.
A reliable sourcing decision starts with traceable product information. I suggest confirming the CAS number, molecular formula, molecular weight, analytical method, purity specification, storage guidance, and available batch documents. If the supplier cannot clearly distinguish a product specification from a general description, the buyer should request clarification before issuing a purchase order.
Research quantities, pilot quantities, and manufacturing quantities can have different pricing and scheduling requirements. Buyers should state the required quantity in grams or kilograms, target delivery date, destination, packaging preference, and whether repeat supply is expected. For example, a request for 500 g may be evaluated differently from a request for 10 kg, particularly when production planning and export documentation are involved.
Technical communication is important when the material will enter a multi-step synthesis. I recommend asking whether the supplier can discuss specification alignment, packaging, document requirements, sample evaluation, and shipment planning. Custom analytical requirements should be agreed in writing so that both parties understand which tests are included and which may require separate arrangements.
Maison Chemical supplies organic boronic acid intermediates for customers involved in research, development, and commercial chemical sourcing. For 3-fluoro-2-methylbenzeneboronic acid CAS 163517-61-1, I can help buyers organize the key information needed for a practical quotation: required quantity, purity target, packaging, destination, documentation, and desired delivery schedule.
Because pricing and availability depend on quantity, batch status, transport route, and specification requirements, I do not present a fixed price or universal lead time without reviewing the inquiry. I can instead help structure a product request that allows the technical and commercial teams to respond accurately. Where the application is sensitive to water, impurities, or process reproducibility, buyers should identify those requirements at the beginning of the discussion.
3-Fluoro-2-methylbenzeneboronic acid CAS 163517-61-1 is a substituted arylboronic acid with an approximate molecular weight of 153.95 g/mol and a primary role as a carbon–carbon coupling building block. Its fluoro and methyl substituents make it relevant to medicinal chemistry, pharmaceutical intermediate development, agrochemical research, and specialty organic synthesis. The correct purchasing decision depends on verified identity, batch-specific quality information, handling requirements, and compatibility with the buyer’s reaction route.
To begin, I recommend preparing a clear inquiry stating the required quantity, purity, intended use, delivery location, packaging needs, and documentation expectations. Maison Chemical can then review the request and provide supplier information appropriate to the project. Before production use, the buyer should confirm the supplied batch against the agreed specification and follow the applicable SDS and internal safety procedures.
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