Sep. 22, 2026
Chemicals
4-Pentylbenzeneboronic acid, also called 4-amylphenylboronic acid, is an aromatic boronic acid used primarily as a research and synthesis intermediate. Its identifying information includes CAS RN 121219-12-3, molecular formula C11H17BO2, and an approximate molecular weight of 192.06 g/mol. The molecule combines a boronic acid group with a para-pentyl-substituted aromatic ring, making it relevant to Suzuki–Miyaura coupling research and the preparation of more complex organic molecules. At Maison Chemical, we support B2B buyers by confirming identity, specification requirements, packaging, documentation, and shipment feasibility before an order is finalized.
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4-Pentylbenzeneboronic acid is an organoboron compound containing a boronic acid functional group, written structurally as an aryl-B(OH)2 unit. The pentyl group is positioned at the 4-position of the phenyl ring relative to the boronic acid substituent. This substitution pattern gives the compound both the reactive behavior associated with arylboronic acids and the nonpolar character contributed by the five-carbon alkyl chain.
The compound is generally considered a specialty organic building block rather than a bulk industrial chemical. Its main value comes from its use in controlled laboratory synthesis, where the boronic acid group can participate in carbon–carbon bond-forming reactions. Because supplier specifications and physical presentation can vary, I recommend treating the identity data below as a starting point and requesting a current product specification or certificate of analysis for procurement decisions.
| Parameter | Information |
|---|---|
| Product name | 4-Pentylbenzeneboronic acid |
| Alternative name | 4-Amylphenylboronic acid |
| CAS RN | 121219-12-3 |
| Molecular formula | C11H17BO2 |
| Approximate molecular weight | 192.06 g/mol |
| Functional group | Arylboronic acid |
The most important synthetic role of 4-pentylbenzeneboronic acid is as an aryl donor in palladium-catalyzed Suzuki–Miyaura coupling. In a typical research workflow, the boronic acid reacts with an aryl or vinyl halide under a suitable catalytic and basic system to form a new carbon–carbon bond. The exact reaction performance depends on the coupling partner, catalyst, base, solvent, temperature, concentration, and work-up conditions, so I do not recommend assuming that one literature procedure will transfer directly to every substrate.
The pentyl substituent can also provide a useful structural feature in target molecules. It may increase hydrophobic character and add steric or spatial requirements to a designed compound, although the practical effect must be evaluated for each molecular system. In medicinal chemistry, materials research, and exploratory organic synthesis, this type of substituted arylboronic acid can therefore serve as a modular fragment for library preparation.
Like other boronic acids, this material should be protected from unnecessary exposure to moisture, contamination, excessive heat, and incompatible reagents. Boronic acids may participate in equilibria involving boronic acid, boronate, and anhydride-related species, and they can be affected by reaction conditions or prolonged storage. The appropriate storage temperature, container, and shelf-life should be based on the supplier’s current specification and the buyer’s own stability assessment.
I advise laboratories to review the safety data sheet before handling and to use suitable personal protective equipment, ventilation, and chemical waste procedures. Appearance, melting behavior, solubility, and assay should not be inferred solely from the chemical name. These properties require product-specific testing or documentation.
Researchers may use 4-pentylbenzeneboronic acid to introduce a 4-pentylphenyl group into a target structure. This can be useful when preparing biaryl, aryl–heteroaryl, or other conjugated compounds through cross-coupling chemistry. The compound is especially relevant when the project requires a hydrophobic alkyl-substituted aromatic fragment rather than an unsubstituted phenylboronic acid.
In medicinal chemistry programs, arylboronic acids are often selected as building blocks for generating structurally diverse analogues. 4-Pentylbenzeneboronic acid can contribute a defined aromatic fragment with a linear five-carbon side chain, allowing researchers to compare analogues with different hydrophobic substituents. Its suitability depends on the desired biological target, downstream purification strategy, and compatibility of the complete reaction sequence.
The compound may also be considered in research involving functional aromatic molecules, organic semiconducting structures, liquid-crystal-related compounds, or other advanced materials intermediates. These uses should be described as potential research applications rather than guaranteed performance areas. Final material properties depend on the full molecular architecture, polymerization or coupling efficiency, purification, and processing conditions.
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For this product, the primary distinction is usually not between different chemical grades with universally fixed definitions, but between supplier-specific specifications and packaging options. A buyer may encounter research-grade material, custom-synthesis material, or a batch supplied against a negotiated assay and impurity profile. The correct choice depends on whether the compound is being used for route scouting, analytical comparison, process development, or a more controlled downstream program.
Packaging can also affect procurement decisions. Small quantities such as 1 g or 10 g may suit feasibility studies, while larger quantities may be requested for repeated analogue synthesis or process investigation. These quantities are purchasing examples rather than a statement of Maison Chemical’s fixed stock position; availability, minimum order quantity, and lead time should be confirmed for each inquiry.
I recommend reviewing more than the product name and CAS number. The most important documents normally include a current certificate of analysis, specification sheet, safety data sheet, and, where appropriate, analytical data such as NMR, HPLC, GC, or LC-MS information. Buyers should confirm whether the reported assay method, impurity limits, water content, residual solvents, and appearance requirements match their internal quality system.
A route-screening project may prioritize availability, consistent identity, and practical pricing, while a regulated or scale-up program may require tighter impurity controls and more extensive documentation. I encourage buyers to provide the intended use, target quantity, required assay, delivery destination, and documentation expectations at the inquiry stage. This information helps prevent a mismatch between a suitable research reagent and a more demanding development specification.
For specialty boronic acids, supply reliability involves more than a single quotation. Buyers should ask whether the product is currently available, made to order, or dependent on upstream intermediates. It is also useful to confirm production or sourcing location, packaging configuration, expected lead time, and whether a retained sample or pre-shipment documentation can be provided.
International chemical shipments require accurate classification, labeling, customs information, and packaging suitable for the material. Storage instructions should follow the supplier’s documentation and the buyer’s facility requirements. If the compound is part of a larger synthesis campaign, purchasing a quantity that supports the planned experiments while limiting unnecessary long-term storage can be a practical risk-control measure.
At Maison Chemical, I approach inquiries for 4-Pentylbenzeneboronic acid CAS 121219-12-3 as specification-matching projects. We can review the requested quantity, target quality level, packaging, destination, and documentation needs before confirming a commercial proposal. Where a buyer has an internal specification, sharing that document allows us to identify the information that must be verified with the manufacturing or quality team.
Our support is intended for research organizations, chemical manufacturers, pharmaceutical and materials companies, and international distributors seeking a responsive specialty-chemical supply channel. We do not replace the buyer’s technical, regulatory, or safety assessment, and we avoid making claims about suitability until the relevant product and application details have been reviewed. This approach helps keep quotations realistic and reduces avoidable sourcing delays.
4-Pentylbenzeneboronic acid CAS 121219-12-3 is a specialized aromatic boronic acid used mainly to introduce a 4-pentylphenyl fragment into research compounds and advanced organic intermediates. Its known identity data provide a clear starting point, but product-specific quality and handling information must come from current supplier documentation. For reliable procurement, buyers should define the required quantity, assay, impurity expectations, packaging, destination, and documents before approving a supplier.
To discuss your requirement with Maison Chemical, send us the CAS number, target quantity, intended application, required specification, delivery location, and preferred timeline. We can then review supply feasibility and provide the appropriate commercial and technical information for your project.
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